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The Yin and Yang of Cannabis: Comparing THC and CBD

3 Mins read

Cannabis is a plant that has been used for medicinal purposes in Thailand for at least a thousand years. However, it wasn’t until the 20th century that scientists began to realize that THC and CBD are the primary chemical compounds responsible for its effects on the human body. Two of the most well-known and studied compounds in cannabis are THC (tetrahydrocannabinol) and CBD (cannabidiol). In this article, we’ll compare and contrast these two compounds and discuss their discovery and interaction.

Discovery of the Dominant Compounds: THC and CBD

The first isolation of THC from cannabis was reported in 1964 by Israeli chemist Dr. Raphael Mechoulam and his colleagues. They were the first to describe the structure of THC and its psychoactive effects. Their research, published in the journal Science, opened up a new field of study in cannabis pharmacology.

Dr. Mechoulam is a renowned Israeli chemist who is best known for his pioneering research into the chemistry and pharmacology of cannabis. Mechoulam was the first scientist to isolate and identify the major psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC). He went on to discover the endocannabinoid system, which plays a crucial role in regulating a wide range of physiological processes in the human body, including pain, appetite, mood, and memory. Mechoulam’s groundbreaking work has greatly expanded our understanding of the potential therapeutic benefits of cannabis and has helped pave the way for the development of new drugs based on cannabis compounds.

In addition to his work on cannabis, Mechoulam has made significant contributions to the field of natural products chemistry. He has isolated and synthesized a number of other important compounds from plants, including the first endogenous compound in the brain to be identified, anandamide. Mechoulam’s research has also shed light on the potential medical uses of other natural products, such as cannabidiol (CBD), a non-psychoactive component of cannabis that has shown promise as a treatment for a range of conditions, including epilepsy, anxiety, and chronic pain. Overall, Dr. Raphael Mechoulam’s groundbreaking research has significantly advanced our understanding of the chemistry and pharmacology of natural products and has opened up new avenues for drug discovery and development.

CBD, on the other hand, was first isolated in 1940 by American chemist Roger Adams. However, its structure was not fully elucidated until much later, in the 1960s, by Mechoulam and his team. Unlike THC, CBD is not psychoactive and does not produce the “high” associated with cannabis use.

Comparing THC and CBD

Despite being derived from the same plant, THC and CBD have very different effects on the body. THC is responsible for the psychoactive effects of cannabis, including the feeling of being “high.” It works by binding to the CB1 receptors in the brain and nervous system, which can lead to a range of effects such as altered perception, euphoria, and increased appetite.

CBD, on the other hand, does not have any psychoactive effects. It works by interacting with the body’s endocannabinoid system, which is involved in regulating a wide range of functions such as mood, appetite, and pain sensation. CBD is thought to have anti-inflammatory, analgesic, and anti-anxiety effects, among others.

The Interaction between THC and CBD

While THC and CBD have different effects on the body, they also interact with each other in interesting ways. For example, some studies have suggested that CBD can modulate the psychoactive effects of THC, reducing the feeling of being “high.” This is because CBD can bind to the same receptors as THC, but in a different way, which can reduce its potency.

Another interesting interaction between THC and CBD is the entourage effect. This refers to the idea that the various compounds in cannabis work together to produce a more potent and diverse range of effects than they would individually. For example, some studies have shown that the presence of CBD can enhance the analgesic effects of THC, making it more effective at reducing pain.

THC and CBD are two key compounds in cannabis that have very different effects on the body. THC is responsible for the psychoactive effects of cannabis, while CBD has no psychoactive effects and is thought to have a range of therapeutic benefits. Despite their differences, THC and CBD interact with each other in interesting ways, which can affect their potency and range of effects. With ongoing research into the pharmacology of cannabis, we may continue to uncover new insights into these fascinating compounds.


  1. Mechoulam, R., & Gaoni, Y. (1964). A total synthesis of dl-Δ1-tetrahydrocannabinol, the active constituent of hashish. Journal of the American Chemical Society, 86(8), 1646-1647.
  2. Adams, R., Hunt, M., & Clark, J. H. (1940). Structure of cannabidiol, a product isolated from the marihuana extract of Minnesota wild hemp. Journal of the American Chemical Society, 62(1),

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I write the # 1 Newsletter for cannabis in Thailand. I call it Cannabis in Thailand. I'm crazy about Cannabis Policy Analysis, Weed Business, Popular Cannabis Science, Thai Cannabis Culture & Cannabis Tourism. I manage Town Hall as Cannabox CCO. Live in Phuket Thailand.
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